Grape Seed Extract (OPC) Benefits for Endurance, Blood Flow & Fat Loss | SCN\u2122<\/title><meta name=\"description\" content=\"Grape seed extract benefits: how 95% proanthocyanidins (OPC) improve endothelial function, lower oxygen cost of exercise, support fat metabolism, blood pressure and skin. 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.pill{display:inline-block;background:var(--gl);color:var(--gd);border-radius:999px;padding:4px 12px;font-weight:700;font-size:.85em;margin:2px 4px 2px 0}\n.scn-cl img.full{max-width:100%;height:auto;border-radius:14px;display:block;margin:16px auto}\n@media(max-width:640px){.scn-cl h1{font-size:1.7em}.scn-cl .hero{padding:26px 20px}.scn-cl .cta{padding:22px}}\n<\/style>\n<div class=\"scn-cl\">\n<div class=\"hero\">\n<span class=\"kick\">Ingredient Guide \u00b7 Grape Seed Extract 95% OPC<\/span><\/p>\n<h1>Grape Seed Extract Benefits: Proanthocyanidins for Blood Flow, Endurance and a Leaner Metabolism<\/h1>\n<p class=\"sub\">Grape seed proanthocyanidins are among the most potent antioxidants in nature \u2014 and in athletes they do something more interesting: they widen arteries, lower the oxygen cost of exercise and extend time to exhaustion.<\/p>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Get Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/p>\n<\/div>\n<p>Oligomeric proanthocyanidins \u2014 <strong>OPCs<\/strong> \u2014 are the polyphenols that make red wine astringent and grape seeds bitter. Standardised to 95%, grape seed extract (GSE) is a concentrated source with antioxidant capacity many times that of vitamins C and E, and a well-documented ability to increase nitric oxide availability in blood vessels.<\/p>\n<p>For endurance athletes, that vascular action is the headline. In a randomised crossover trial in elite basketball players, 300 mg\/day of GSE for just 14 days increased flow-mediated dilation (a direct measure of artery function), reduced oxygen consumption at 80% and 120% of VO\u2082peak and increased time to exhaustion (Nho & Kim 2022). Meta-analyses in the general population show GSE lowers blood pressure, improves circulation and reduces oxidation of LDL cholesterol; metabolic studies show reduced fat accumulation and better post-meal glucose handling.<\/p>\n<p><a href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\"><strong>Carni-Lipolysis Active\u00b9\u00b2<\/strong><\/a> contains 150 mg of 95% grape seed extract (142.5 mg proanthocyanidins) per sachet, supporting blood flow to working muscle, antioxidant defence and the glucose-handling complex alongside berberine, cinnamon and inositol.<\/p>\n<div class=\"cta\">\n<div>\n<h3>More oxygen to the muscle. Less oxygen per watt.<\/h3>\n<p>Carni-Lipolysis Active\u00b9\u00b2 combines grape seed OPC with 3,000 mg carnitine, EGCG and Capsimax\u00ae \u2014 the stimulant-free fat burner that also improves blood flow.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Shop Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>How does grape seed extract work? The mechanism explained<\/h2>\n<h3>Nitric oxide and endothelial function<\/h3>\n<p>OPCs activate endothelial nitric-oxide synthase (eNOS) and protect nitric oxide from oxidative destruction, relaxing arterial smooth muscle. The result is measurable: increased flow-mediated dilation and lower blood pressure in controlled trials.<\/p>\n<h3>Antioxidant capacity<\/h3>\n<p>Proanthocyanidins scavenge superoxide, hydroxyl and peroxyl radicals, chelate transition metals and regenerate vitamin C and E \u2014 protecting LDL, cell membranes and DNA from the oxidative load of training and daily life.<\/p>\n<h3>Metabolic actions<\/h3>\n<p>GSE inhibits pancreatic lipase and \u03b1-amylase (reducing fat and starch digestion), activates AMPK and SIRT1 pathways, reduces fat accumulation in adipose and liver tissue in experimental models, and improves post-meal glucose and insulin responses in humans.<\/p>\n<h3>Collagen protection<\/h3>\n<p>OPCs bind to collagen and elastin fibres, protecting them from enzymatic degradation \u2014 the basis of their benefits for vessel walls, skin and connective tissue.<\/p>\n<h2>What are the sports performance benefits of grape seed extract?<\/h2>\n<p>Grape seed extract is one of the few polyphenols with human performance data generated in trained athletes.<\/p>\n<h3>1. Does grape seed extract improve blood flow during exercise?<\/h3>\n<p>Yes. In elite basketball players, 300 mg\/day for 14 days significantly increased flow-mediated dilation of the brachial artery compared with placebo \u2014 more arterial dilation means more oxygen delivery to working muscle.<\/p>\n<h3>2. Does it lower the oxygen cost of exercise?<\/h3>\n<p>In the same trial, oxygen consumption at 80% and 120% of VO\u2082peak was lower after GSE, indicating improved exercise economy \u2014 the same output for less oxygen.<\/p>\n<h3>3. Does grape seed extract increase time to exhaustion?<\/h3>\n<p>Yes \u2014 time to exhaustion at 120% VO\u2082peak increased after GSE versus placebo, a direct performance gain in a supramaximal test.<\/p>\n<h3>4. Does it speed oxygen delivery at exercise onset?<\/h3>\n<p>A 2022 study found grape seed extract accelerated oxygen-uptake kinetics at the start of exercise, reducing the oxygen deficit in the first minutes \u2014 valuable for surges, climbs and race starts.<\/p>\n<h3>5. Does grape seed extract reduce exercise-induced oxidative stress?<\/h3>\n<p>Its potent antioxidant action lowers markers of lipid peroxidation after intense exercise and supports recovery of muscle function.<\/p>\n<h3>6. Does it support recovery and reduce soreness?<\/h3>\n<p>By protecting membranes and reducing inflammatory signalling, GSE supports faster recovery; proanthocyanidin-rich extracts have reduced muscle-damage markers in several trials.<\/p>\n<h3>7. Does grape seed extract support fat loss in athletes?<\/h3>\n<p>GSE reduces fat accumulation in experimental models, modestly inhibits dietary fat absorption and improves post-meal glucose handling \u2014 complementing the carnitine and Capsimax\u00ae in Carni-Lipolysis Active\u00b9\u00b2.<\/p>\n<h3>8. Does it support healthy blood pressure in hard-training athletes?<\/h3>\n<p>A meta-analysis of 16 trials (810 people) found GSE lowered systolic blood pressure by about 6 mmHg and diastolic by 2.8 mmHg, with the biggest effect in younger people with higher BMI.<\/p>\n<div class=\"cta\">\n<div>\n<h3>Open the arteries. Feed the muscle.<\/h3>\n<p>Carni-Lipolysis Active\u00b9\u00b2: grape seed OPC for blood flow, carnitine for fat transport, Capsimax\u00ae and EGCG for thermogenesis.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Order Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>What are the health benefits of grape seed extract?<\/h2>\n<p>Grape seed extract’s health research spans cardiovascular, metabolic, skin and cognitive outcomes.<\/p>\n<h3>1. Does grape seed extract support healthy blood pressure?<\/h3>\n<p>Yes. Meta-analyses of randomised trials show significant reductions in systolic and diastolic pressure, especially in people under 50 with metabolic risk factors.<\/p>\n<h3>2. Does it improve circulation?<\/h3>\n<p>GSE improves endothelial function and venous tone and reduces leg swelling in trials \u2014 benefits for anyone who sits, stands or flies long hours.<\/p>\n<h3>3. Does grape seed extract protect cholesterol from oxidation?<\/h3>\n<p>OPCs inhibit LDL oxidation, the step that makes cholesterol harmful to artery walls.<\/p>\n<h3>4. Does it support normal blood sugar?<\/h3>\n<p>GSE improves post-meal glucose and insulin responses and supports normal insulin sensitivity in metabolic studies.<\/p>\n<h3>5. Does grape seed extract support brain health?<\/h3>\n<p>Grape-derived polyphenols cross into the brain and support cognitive function and resilience to oxidative stress in aging studies.<\/p>\n<h3>6. Does it support skin and collagen?<\/h3>\n<p>OPCs protect collagen and elastin, improve skin elasticity and support wound healing; they also protect against UV-induced oxidative damage.<\/p>\n<h3>7. Does grape seed extract support eye health?<\/h3>\n<p>Proanthocyanidins support retinal microcirculation and protect against oxidative damage in the eye.<\/p>\n<h3>8. Does it support healthy weight?<\/h3>\n<p>By inhibiting lipase and \u03b1-amylase and activating AMPK, GSE reduces fat accumulation in experimental models and supports a healthy metabolic profile.<\/p>\n<h2>grape seed extract for endurance athletes: who benefits most?<\/h2>\n<div class=\"aud\">\n<h3>Runners<\/h3>\n<p>Lower oxygen cost at race pace is free speed. Grape seed OPC improved exercise economy and time to exhaustion in two weeks \u2014 take it daily through the build and into race week.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Cyclists<\/h3>\n<p>Climbing is oxygen delivery. GSE widens arteries, speeds oxygen kinetics at the start of efforts and lowers oxygen consumption at threshold \u2014 exactly what attacks and climbs demand.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Triathletes<\/h3>\n<p>Vascular function matters in every discipline, and GSE’s blood-pressure and antioxidant benefits protect the cardiovascular system under triathlon’s enormous training loads.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Swimmers<\/h3>\n<p>Supramaximal sets at 120% VO\u2082peak are where GSE extended time to exhaustion. Better oxygen delivery and lower oxidative stress support both the set and the recovery.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Marathon runners<\/h3>\n<p>Marathon economy decides the last 10 km. Daily GSE improves exercise economy and protects against the oxidative stress of high mileage, supporting recovery between long runs.<\/p>\n<\/div>\n<div class=\"cta\">\n<div>\n<h3>Two weeks to better economy.<\/h3>\n<p>Order Carni-Lipolysis Active\u00b9\u00b2 and get grape seed OPC with eleven other metabolic actives \u2014 stimulant-free.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Buy Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>How much grape seed extract do you need, and when should you take it?<\/h2>\n<p>Trials use <strong>100\u2013300 mg grape seed extract per day<\/strong> for vascular and performance benefits, and up to 2,000 mg in blood-pressure studies; 300 mg\/day for 14 days improved athletic performance.<\/p>\n<p><strong>Carni-Lipolysis Active\u00b9\u00b2<\/strong> provides 150 mg GSE (142.5 mg OPC) per sachet \u2014 300 mg at the daily dose, matching the athlete trial \u2014 alongside 3,000 mg carnitine, Capsimax\u00ae, EGCG, berberine, cinnamon, inositol, choline, NALT and BioPerine\u00ae.<\/p>\n<p>For higher single-session doses, <a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">Pre-Endurance Training Activator<\/a> supplies 600 mg GSE (570 mg OPC) per sachet. GSE is very well tolerated; those on anticoagulants should consult their doctor.<\/p>\n<h2>Which SCN\u2122 products contain grape seed extract?<\/h2>\n<p>Grape seed OPC is a signature SCN\u2122 ingredient, used across six formulas for blood flow and antioxidant protection.<\/p>\n<div class=\"grid\">\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Carni-Lipolysis Active\u00b9\u00b2<\/a><\/h4>\n<p>150 mg grape seed extract 95% (142.5 mg OPC) per sachet in the stimulant-free fat burner with 3,000 mg carnitine, Capsimax\u00ae, EGCG and berberine.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">Pre-Endurance Training Activator<\/a><\/h4>\n<p>600 mg grape seed extract (570 mg OPC) per sachet \u2014 the highest GSE dose in the range \u2014 with citrulline, arginine nitrate and tyrosine.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-power-vo2-max-supplement\/\" data-wpel-link=\"external\" rel=\"noopener\">Krebs Cycle Accelerator\u2074\u2070<\/a><\/h4>\n<p>300 mg grape extract 95% (285 mg OPC) plus 200 mg maritime pine OPC in Krebs Cycle Accelerator\u2074\u2070.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-power-vo2-max-supplement\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/glp1-fatburner\/\" data-wpel-link=\"external\" rel=\"noopener\">Fat & Glucose Metabolizer<\/a><\/h4>\n<p>40 mg grape seed OPC plus 40 mg pine bark OPC alongside 582 mg berberine, cinnamon and Capsimax\u00ae in Fat & Glucose Metabolizer.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/glp1-fatburner\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/ubiquinol-forte-ubiquinol-curcumin-proanthocyanidin-bioperine\/\" data-wpel-link=\"external\" rel=\"noopener\">Ubiquinol Forte<\/a><\/h4>\n<p>100 mg grape seed extract (95 mg OPC) with 250 mg Kaneka ubiquinol, curcumin and BioPerine\u00ae in Ubiquinol Forte.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/ubiquinol-forte-ubiquinol-curcumin-proanthocyanidin-bioperine\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/race-max-pro-pre-race-performance-vo2max-enhancer\/\" data-wpel-link=\"external\" rel=\"noopener\">Race Max Pro<\/a><\/h4>\n<p>100 mg grape seed extract 95% (95 mg OPC) with sodium bicarbonate and R-ALA in Race Max Pro.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/race-max-pro-pre-race-performance-vo2max-enhancer\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<\/div>\n<h2>Frequently asked questions about grape seed extract<\/h2>\n<div class='faq'>\n<details>\n<summary>What are OPCs?<\/summary>\n<p>Oligomeric proanthocyanidins \u2014 chains of catechin and epicatechin units. They are the active polyphenols in grape seed and pine bark extracts, responsible for the vascular and antioxidant effects.<\/p>\n<\/details>\n<details>\n<summary>Is grape seed extract the same as resveratrol?<\/summary>\n<p>No. Resveratrol comes from grape skin; grape seed extract is rich in proanthocyanidins. They are complementary polyphenols with different mechanisms.<\/p>\n<\/details>\n<details>\n<summary>How quickly does grape seed extract work?<\/summary>\n<p>Vascular effects appear within hours of a dose; the athlete trial showed performance gains after 14 days of daily use.<\/p>\n<\/details>\n<details>\n<summary>Is grape seed extract safe long-term?<\/summary>\n<p>Yes \u2014 trials up to 12 months show excellent tolerability. Those on blood thinners should consult their doctor.<\/p>\n<\/details>\n<details>\n<summary>Does grape seed extract contain alcohol or sugar?<\/summary>\n<p>No. It is a dry polyphenol extract from seeds.<\/p>\n<\/details>\n<\/div>\n<div class=\"hero\" style=\"text-align:center;margin-top:30px\">\n<span class=\"kick\">SCN\u2122 \u00b7 Made in Europe \u00b7 100% doping-free<\/span><\/p>\n<h2 style=\"margin-top:6px\">Nature’s most powerful antioxidant \u2014 put to work on your watts.<\/h2>\n<p class=\"sub\" style=\"margin:0 auto 18px\">Carni-Lipolysis Active\u00b9\u00b2 delivers 300 mg grape seed OPC daily inside a 12-active, stimulant-free fat burner.<\/p>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Add Carni-Lipolysis Active\u00b9\u00b2 to basket \u2192<\/a>\n<\/div>\n<h2>Scientific references<\/h2>\n<ol class='refs'>\n<li>Nho H, Kim KA. Effects of grape seed extract supplementation on endothelial function and endurance performance in basketball players. Int J Environ Res Public Health 2022;19:14223.<\/li>\n<li>Zhang H et al. The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials. Medicine (Baltimore) 2016;95:e4247.<\/li>\n<li>Fernandes de Oliveira Ferreira Freitas et al. Grape seed extract speeds oxygen uptake kinetics at exercise onset. Nutrients 2022 (reported by NutraIngredients, Jan 2022).<\/li>\n<li>Bagchi D et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000;148:187\u2013197.<\/li>\n<li>Pascual-Serrano A et al. Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats. Int J Obes 2017;41:1246\u20131255.<\/li>\n<li>Sano A et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol 2007;53:174\u2013182.<\/li>\n<\/ol>\n<p class=\"small\"><em>Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. This content is for education and general information and does not replace advice from your doctor or dietitian. Do not exceed the recommended daily dose. Keep out of reach of young children. Not intended for pregnant or breastfeeding women. If you take medication or have a medical condition, consult a healthcare professional before use.<\/em><\/p>\n<\/div>\n<p><br \/>\n<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Grape Seed Extract (OPC) Benefits for Endurance, Blood Flow & Fat Loss | SCN\u2122 Ingredient Guide \u00b7 Grape Seed Extract 95% OPC Grape Seed Extract Benefits: Proanthocyanidins for Blood Flow, Endurance and a Leaner Metabolism Grape seed proanthocyanidins are among the most potent antioxidants in nature \u2014 and in athletes they do something more interesting: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"page_builder":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-13266","post","type-post","status-publish","format-standard","category-scn-power"],"_links":{"self":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/comments?post=13266"}],"version-history":[{"count":2,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266\/revisions"}],"predecessor-version":[{"id":13388,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266\/revisions\/13388"}],"wp:attachment":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/media?parent=13266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/categories?post=13266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/tags?post=13266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":13266,"date":"2026-10-28T22:25:07","date_gmt":"2026-10-28T19:25:07","guid":{"rendered":"https:\/\/www.s-c-nutrition.com\/?p=13266"},"modified":"2026-10-29T17:40:37","modified_gmt":"2026-10-29T14:40:37","slug":"grape-seed-extract-benefits","status":"publish","type":"post","link":"https:\/\/www.s-c-nutrition.com\/hi\/grape-seed-extract-benefits\/","title":{"rendered":"Grape Seed Extract Benefits: Proanthocyanidins for Blood Flow, Endurance and a Leaner Metabolism"},"content":{"rendered":"

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.pill{display:inline-block;background:var(--gl);color:var(--gd);border-radius:999px;padding:4px 12px;font-weight:700;font-size:.85em;margin:2px 4px 2px 0}\n.scn-cl img.full{max-width:100%;height:auto;border-radius:14px;display:block;margin:16px auto}\n@media(max-width:640px){.scn-cl h1{font-size:1.7em}.scn-cl .hero{padding:26px 20px}.scn-cl .cta{padding:22px}}\n<\/style>\n<div class=\"scn-cl\">\n<div class=\"hero\">\n<span class=\"kick\">Ingredient Guide \u00b7 Grape Seed Extract 95% OPC<\/span><\/p>\n<h1>Grape Seed Extract Benefits: Proanthocyanidins for Blood Flow, Endurance and a Leaner Metabolism<\/h1>\n<p class=\"sub\">Grape seed proanthocyanidins are among the most potent antioxidants in nature \u2014 and in athletes they do something more interesting: they widen arteries, lower the oxygen cost of exercise and extend time to exhaustion.<\/p>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Get Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/p>\n<\/div>\n<p>Oligomeric proanthocyanidins \u2014 <strong>OPCs<\/strong> \u2014 are the polyphenols that make red wine astringent and grape seeds bitter. Standardised to 95%, grape seed extract (GSE) is a concentrated source with antioxidant capacity many times that of vitamins C and E, and a well-documented ability to increase nitric oxide availability in blood vessels.<\/p>\n<p>For endurance athletes, that vascular action is the headline. In a randomised crossover trial in elite basketball players, 300 mg\/day of GSE for just 14 days increased flow-mediated dilation (a direct measure of artery function), reduced oxygen consumption at 80% and 120% of VO\u2082peak and increased time to exhaustion (Nho & Kim 2022). Meta-analyses in the general population show GSE lowers blood pressure, improves circulation and reduces oxidation of LDL cholesterol; metabolic studies show reduced fat accumulation and better post-meal glucose handling.<\/p>\n<p><a href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\"><strong>Carni-Lipolysis Active\u00b9\u00b2<\/strong><\/a> contains 150 mg of 95% grape seed extract (142.5 mg proanthocyanidins) per sachet, supporting blood flow to working muscle, antioxidant defence and the glucose-handling complex alongside berberine, cinnamon and inositol.<\/p>\n<div class=\"cta\">\n<div>\n<h3>More oxygen to the muscle. Less oxygen per watt.<\/h3>\n<p>Carni-Lipolysis Active\u00b9\u00b2 combines grape seed OPC with 3,000 mg carnitine, EGCG and Capsimax\u00ae \u2014 the stimulant-free fat burner that also improves blood flow.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Shop Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>How does grape seed extract work? The mechanism explained<\/h2>\n<h3>Nitric oxide and endothelial function<\/h3>\n<p>OPCs activate endothelial nitric-oxide synthase (eNOS) and protect nitric oxide from oxidative destruction, relaxing arterial smooth muscle. The result is measurable: increased flow-mediated dilation and lower blood pressure in controlled trials.<\/p>\n<h3>Antioxidant capacity<\/h3>\n<p>Proanthocyanidins scavenge superoxide, hydroxyl and peroxyl radicals, chelate transition metals and regenerate vitamin C and E \u2014 protecting LDL, cell membranes and DNA from the oxidative load of training and daily life.<\/p>\n<h3>Metabolic actions<\/h3>\n<p>GSE inhibits pancreatic lipase and \u03b1-amylase (reducing fat and starch digestion), activates AMPK and SIRT1 pathways, reduces fat accumulation in adipose and liver tissue in experimental models, and improves post-meal glucose and insulin responses in humans.<\/p>\n<h3>Collagen protection<\/h3>\n<p>OPCs bind to collagen and elastin fibres, protecting them from enzymatic degradation \u2014 the basis of their benefits for vessel walls, skin and connective tissue.<\/p>\n<h2>What are the sports performance benefits of grape seed extract?<\/h2>\n<p>Grape seed extract is one of the few polyphenols with human performance data generated in trained athletes.<\/p>\n<h3>1. Does grape seed extract improve blood flow during exercise?<\/h3>\n<p>Yes. In elite basketball players, 300 mg\/day for 14 days significantly increased flow-mediated dilation of the brachial artery compared with placebo \u2014 more arterial dilation means more oxygen delivery to working muscle.<\/p>\n<h3>2. Does it lower the oxygen cost of exercise?<\/h3>\n<p>In the same trial, oxygen consumption at 80% and 120% of VO\u2082peak was lower after GSE, indicating improved exercise economy \u2014 the same output for less oxygen.<\/p>\n<h3>3. Does grape seed extract increase time to exhaustion?<\/h3>\n<p>Yes \u2014 time to exhaustion at 120% VO\u2082peak increased after GSE versus placebo, a direct performance gain in a supramaximal test.<\/p>\n<h3>4. Does it speed oxygen delivery at exercise onset?<\/h3>\n<p>A 2022 study found grape seed extract accelerated oxygen-uptake kinetics at the start of exercise, reducing the oxygen deficit in the first minutes \u2014 valuable for surges, climbs and race starts.<\/p>\n<h3>5. Does grape seed extract reduce exercise-induced oxidative stress?<\/h3>\n<p>Its potent antioxidant action lowers markers of lipid peroxidation after intense exercise and supports recovery of muscle function.<\/p>\n<h3>6. Does it support recovery and reduce soreness?<\/h3>\n<p>By protecting membranes and reducing inflammatory signalling, GSE supports faster recovery; proanthocyanidin-rich extracts have reduced muscle-damage markers in several trials.<\/p>\n<h3>7. Does grape seed extract support fat loss in athletes?<\/h3>\n<p>GSE reduces fat accumulation in experimental models, modestly inhibits dietary fat absorption and improves post-meal glucose handling \u2014 complementing the carnitine and Capsimax\u00ae in Carni-Lipolysis Active\u00b9\u00b2.<\/p>\n<h3>8. Does it support healthy blood pressure in hard-training athletes?<\/h3>\n<p>A meta-analysis of 16 trials (810 people) found GSE lowered systolic blood pressure by about 6 mmHg and diastolic by 2.8 mmHg, with the biggest effect in younger people with higher BMI.<\/p>\n<div class=\"cta\">\n<div>\n<h3>Open the arteries. Feed the muscle.<\/h3>\n<p>Carni-Lipolysis Active\u00b9\u00b2: grape seed OPC for blood flow, carnitine for fat transport, Capsimax\u00ae and EGCG for thermogenesis.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Order Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>What are the health benefits of grape seed extract?<\/h2>\n<p>Grape seed extract’s health research spans cardiovascular, metabolic, skin and cognitive outcomes.<\/p>\n<h3>1. Does grape seed extract support healthy blood pressure?<\/h3>\n<p>Yes. Meta-analyses of randomised trials show significant reductions in systolic and diastolic pressure, especially in people under 50 with metabolic risk factors.<\/p>\n<h3>2. Does it improve circulation?<\/h3>\n<p>GSE improves endothelial function and venous tone and reduces leg swelling in trials \u2014 benefits for anyone who sits, stands or flies long hours.<\/p>\n<h3>3. Does grape seed extract protect cholesterol from oxidation?<\/h3>\n<p>OPCs inhibit LDL oxidation, the step that makes cholesterol harmful to artery walls.<\/p>\n<h3>4. Does it support normal blood sugar?<\/h3>\n<p>GSE improves post-meal glucose and insulin responses and supports normal insulin sensitivity in metabolic studies.<\/p>\n<h3>5. Does grape seed extract support brain health?<\/h3>\n<p>Grape-derived polyphenols cross into the brain and support cognitive function and resilience to oxidative stress in aging studies.<\/p>\n<h3>6. Does it support skin and collagen?<\/h3>\n<p>OPCs protect collagen and elastin, improve skin elasticity and support wound healing; they also protect against UV-induced oxidative damage.<\/p>\n<h3>7. Does grape seed extract support eye health?<\/h3>\n<p>Proanthocyanidins support retinal microcirculation and protect against oxidative damage in the eye.<\/p>\n<h3>8. Does it support healthy weight?<\/h3>\n<p>By inhibiting lipase and \u03b1-amylase and activating AMPK, GSE reduces fat accumulation in experimental models and supports a healthy metabolic profile.<\/p>\n<h2>grape seed extract for endurance athletes: who benefits most?<\/h2>\n<div class=\"aud\">\n<h3>Runners<\/h3>\n<p>Lower oxygen cost at race pace is free speed. Grape seed OPC improved exercise economy and time to exhaustion in two weeks \u2014 take it daily through the build and into race week.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Cyclists<\/h3>\n<p>Climbing is oxygen delivery. GSE widens arteries, speeds oxygen kinetics at the start of efforts and lowers oxygen consumption at threshold \u2014 exactly what attacks and climbs demand.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Triathletes<\/h3>\n<p>Vascular function matters in every discipline, and GSE’s blood-pressure and antioxidant benefits protect the cardiovascular system under triathlon’s enormous training loads.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Swimmers<\/h3>\n<p>Supramaximal sets at 120% VO\u2082peak are where GSE extended time to exhaustion. Better oxygen delivery and lower oxidative stress support both the set and the recovery.<\/p>\n<\/div>\n<div class=\"aud\">\n<h3>Marathon runners<\/h3>\n<p>Marathon economy decides the last 10 km. Daily GSE improves exercise economy and protects against the oxidative stress of high mileage, supporting recovery between long runs.<\/p>\n<\/div>\n<div class=\"cta\">\n<div>\n<h3>Two weeks to better economy.<\/h3>\n<p>Order Carni-Lipolysis Active\u00b9\u00b2 and get grape seed OPC with eleven other metabolic actives \u2014 stimulant-free.<\/p>\n<\/div>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Buy Carni-Lipolysis Active\u00b9\u00b2 \u2192<\/a><\/div>\n<h2>How much grape seed extract do you need, and when should you take it?<\/h2>\n<p>Trials use <strong>100\u2013300 mg grape seed extract per day<\/strong> for vascular and performance benefits, and up to 2,000 mg in blood-pressure studies; 300 mg\/day for 14 days improved athletic performance.<\/p>\n<p><strong>Carni-Lipolysis Active\u00b9\u00b2<\/strong> provides 150 mg GSE (142.5 mg OPC) per sachet \u2014 300 mg at the daily dose, matching the athlete trial \u2014 alongside 3,000 mg carnitine, Capsimax\u00ae, EGCG, berberine, cinnamon, inositol, choline, NALT and BioPerine\u00ae.<\/p>\n<p>For higher single-session doses, <a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">Pre-Endurance Training Activator<\/a> supplies 600 mg GSE (570 mg OPC) per sachet. GSE is very well tolerated; those on anticoagulants should consult their doctor.<\/p>\n<h2>Which SCN\u2122 products contain grape seed extract?<\/h2>\n<p>Grape seed OPC is a signature SCN\u2122 ingredient, used across six formulas for blood flow and antioxidant protection.<\/p>\n<div class=\"grid\">\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Carni-Lipolysis Active\u00b9\u00b2<\/a><\/h4>\n<p>150 mg grape seed extract 95% (142.5 mg OPC) per sachet in the stimulant-free fat burner with 3,000 mg carnitine, Capsimax\u00ae, EGCG and berberine.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">Pre-Endurance Training Activator<\/a><\/h4>\n<p>600 mg grape seed extract (570 mg OPC) per sachet \u2014 the highest GSE dose in the range \u2014 with citrulline, arginine nitrate and tyrosine.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-pre-workout\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-power-vo2-max-supplement\/\" data-wpel-link=\"external\" rel=\"noopener\">Krebs Cycle Accelerator\u2074\u2070<\/a><\/h4>\n<p>300 mg grape extract 95% (285 mg OPC) plus 200 mg maritime pine OPC in Krebs Cycle Accelerator\u2074\u2070.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/endurance-power-vo2-max-supplement\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/glp1-fatburner\/\" data-wpel-link=\"external\" rel=\"noopener\">Fat & Glucose Metabolizer<\/a><\/h4>\n<p>40 mg grape seed OPC plus 40 mg pine bark OPC alongside 582 mg berberine, cinnamon and Capsimax\u00ae in Fat & Glucose Metabolizer.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/glp1-fatburner\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/ubiquinol-forte-ubiquinol-curcumin-proanthocyanidin-bioperine\/\" data-wpel-link=\"external\" rel=\"noopener\">Ubiquinol Forte<\/a><\/h4>\n<p>100 mg grape seed extract (95 mg OPC) with 250 mg Kaneka ubiquinol, curcumin and BioPerine\u00ae in Ubiquinol Forte.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/ubiquinol-forte-ubiquinol-curcumin-proanthocyanidin-bioperine\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<div class=\"card\">\n<h4><a href=\"https:\/\/www.s-c-nutrition.com\/product\/race-max-pro-pre-race-performance-vo2max-enhancer\/\" data-wpel-link=\"external\" rel=\"noopener\">Race Max Pro<\/a><\/h4>\n<p>100 mg grape seed extract 95% (95 mg OPC) with sodium bicarbonate and R-ALA in Race Max Pro.<\/p>\n<p style=\"margin-top:8px\"><a class=\"btn ghost\" style=\"padding:8px 16px;font-size:.9em\" href=\"https:\/\/www.s-c-nutrition.com\/product\/race-max-pro-pre-race-performance-vo2max-enhancer\/\" data-wpel-link=\"external\" rel=\"noopener\">View product \u2192<\/a><\/p>\n<\/div>\n<\/div>\n<h2>Frequently asked questions about grape seed extract<\/h2>\n<div class='faq'>\n<details>\n<summary>What are OPCs?<\/summary>\n<p>Oligomeric proanthocyanidins \u2014 chains of catechin and epicatechin units. They are the active polyphenols in grape seed and pine bark extracts, responsible for the vascular and antioxidant effects.<\/p>\n<\/details>\n<details>\n<summary>Is grape seed extract the same as resveratrol?<\/summary>\n<p>No. Resveratrol comes from grape skin; grape seed extract is rich in proanthocyanidins. They are complementary polyphenols with different mechanisms.<\/p>\n<\/details>\n<details>\n<summary>How quickly does grape seed extract work?<\/summary>\n<p>Vascular effects appear within hours of a dose; the athlete trial showed performance gains after 14 days of daily use.<\/p>\n<\/details>\n<details>\n<summary>Is grape seed extract safe long-term?<\/summary>\n<p>Yes \u2014 trials up to 12 months show excellent tolerability. Those on blood thinners should consult their doctor.<\/p>\n<\/details>\n<details>\n<summary>Does grape seed extract contain alcohol or sugar?<\/summary>\n<p>No. It is a dry polyphenol extract from seeds.<\/p>\n<\/details>\n<\/div>\n<div class=\"hero\" style=\"text-align:center;margin-top:30px\">\n<span class=\"kick\">SCN\u2122 \u00b7 Made in Europe \u00b7 100% doping-free<\/span><\/p>\n<h2 style=\"margin-top:6px\">Nature’s most powerful antioxidant \u2014 put to work on your watts.<\/h2>\n<p class=\"sub\" style=\"margin:0 auto 18px\">Carni-Lipolysis Active\u00b9\u00b2 delivers 300 mg grape seed OPC daily inside a 12-active, stimulant-free fat burner.<\/p>\n<p><a class=\"btn\" href=\"https:\/\/www.s-c-nutrition.com\/product\/fatloss-diet-weightloss-carnitine\/\" data-wpel-link=\"external\" rel=\"noopener\">Add Carni-Lipolysis Active\u00b9\u00b2 to basket \u2192<\/a>\n<\/div>\n<h2>Scientific references<\/h2>\n<ol class='refs'>\n<li>Nho H, Kim KA. Effects of grape seed extract supplementation on endothelial function and endurance performance in basketball players. Int J Environ Res Public Health 2022;19:14223.<\/li>\n<li>Zhang H et al. The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials. Medicine (Baltimore) 2016;95:e4247.<\/li>\n<li>Fernandes de Oliveira Ferreira Freitas et al. Grape seed extract speeds oxygen uptake kinetics at exercise onset. Nutrients 2022 (reported by NutraIngredients, Jan 2022).<\/li>\n<li>Bagchi D et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000;148:187\u2013197.<\/li>\n<li>Pascual-Serrano A et al. Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats. Int J Obes 2017;41:1246\u20131255.<\/li>\n<li>Sano A et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol 2007;53:174\u2013182.<\/li>\n<\/ol>\n<p class=\"small\"><em>Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. This content is for education and general information and does not replace advice from your doctor or dietitian. Do not exceed the recommended daily dose. Keep out of reach of young children. Not intended for pregnant or breastfeeding women. If you take medication or have a medical condition, consult a healthcare professional before use.<\/em><\/p>\n<\/div>\n<p><br \/>\n<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Grape Seed Extract (OPC) Benefits for Endurance, Blood Flow & Fat Loss | SCN\u2122 Ingredient Guide \u00b7 Grape Seed Extract 95% OPC Grape Seed Extract Benefits: Proanthocyanidins for Blood Flow, Endurance and a Leaner Metabolism Grape seed proanthocyanidins are among the most potent antioxidants in nature \u2014 and in athletes they do something more interesting: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"page_builder":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-13266","post","type-post","status-publish","format-standard","category-scn-power"],"_links":{"self":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/comments?post=13266"}],"version-history":[{"count":2,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266\/revisions"}],"predecessor-version":[{"id":13388,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/posts\/13266\/revisions\/13388"}],"wp:attachment":[{"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/media?parent=13266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/categories?post=13266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.s-c-nutrition.com\/hi\/wp-json\/wp\/v2\/tags?post=13266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}